Title: Use-dependent block of I-h in mouse dorsal root ganglion neurons by sinus node inhibitors
Authors: Raes, Adam
Van de Vijver, G
Goethals, M
van Bogaert, PP #
Issue Date: Oct-1998
Publisher: Stockton press
Series Title: British Journal of Pharmacology vol:125 issue:4 pages:741-750
Abstract: 1 The sinus node inhibitors UL-FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a hyperpolarization-activated current I-f. A hyperpolarization-activated current I-h, which is present in many types of neurons, is similar to I-f. We studied the effects of these drugs on I-h in cultured mouse dorsal root ganglion (DRG) neurons.
ISSN: 0007-1188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
# (joint) last author

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