Title: The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation
Authors: Garoff, H ×
Huylebroeck, Danny
Robinson, A
Tillman, U
Liljeström, P #
Issue Date: Oct-1990
Series Title: Journal of Cell Biology vol:111 issue:3 pages:867-76
Abstract: So far it has been demonstrated that the signal sequence of proteins which are made at the ER functions both at the level of protein targeting to the ER and in initiation of chain translocation across the ER membrane. However, its possible role in completing the process of chain transfer (see Singer, S. J., P. A. Maher, and M. P. Yaffe. Proc. Natl. Acad. Sci. USA. 1987. 84:1015-1019) has remained elusive. In this work we show that the p62 protein of Semliki Forest virus contains an uncleaved signal sequence at its NH2-terminus and that this becomes glycosylated early during synthesis and translocation of the p62 polypeptide. As the glycosylation of the signal sequence most likely occurs after its release from the ER membrane our results suggest that this region has no role in completing the transfer process.
ISSN: 0021-9525
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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