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Title: Opposite effects of growth hormone and estrogens on the pregnancy zone protein serum levels in children and adolescents
Authors: Devriendt, Koenraad ×
Massa, G
de Zegher, Francis
Vanderschueren-Lodeweyckx, Magda
Cassiman, Jean-Jacques
Van den Berghe, Herman
Marynen, Peter #
Issue Date: Jun-1993
Publisher: BioScientifica Ltd.
Series Title: European Journal of Endocrinology vol:128 issue:4 pages:334-338
Abstract: Serum levels of pregnancy zone protein were measured in children with growth hormone deficiency and in girls with Turner syndrome, before and during treatment with recombinant human growth hormone and in healthy controls. The pregnancy zone protein serum levels in growth hormone deficiency patients before treatment were significantly higher than in controls (median value 2420 micrograms/l vs 434 micrograms/l; p < or = 0.001). In Turner syndrome patients they were within the normal range. The administration of rhGH to both growth hormone deficiency and Turner syndrome patients resulted in a significant decrease in the serum pregnancy zone protein levels by approximately 50%. The addition of 50 ethinylestradiol to the growth hormone treatment in Turner syndrome patients led to an increase in pregnancy zone protein concentrations in four out of five patients. Elevated pregnancy zone protein levels were also found in two children with growth hormone resistance (Laron type dwarfism). In one patient with placental growth hormone deficiency, pregnancy zone protein serum levels during pregnancy were within the normal range. These results suggest that the serum pregnancy zone protein levels are down-regulated by growth hormone.
ISSN: 0804-4643
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
Molecular Genetics Section (-)
Section Newborn (-)
Forensic Biomedical Sciences
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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