Title: Differential protein expression profile in gastrointestinal stromal tumors
Authors: Landuyt, Bart ×
Prenen, Hans
Debiec-Rychter, Maria
Sciot, Raphael
de Bruijn, E A
Van Oosterom, Allan #
Issue Date: Dec-2004
Series Title: Amino acids. vol:27 issue:3-4 pages:335-7
Abstract: Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal through gain of function mutations of the oncogene KIT. Imatinib offers the first effective treatment for patients with GISTs, but the therapeutic outcome strongly depends on the type of KIT mutation. We used ProteinChip technology to investigate whether GISTs with different KIT mutations express different proteins. In total, 154 proteins were significantly differentially expressed in GISTs with exon 9 KIT mutation compared to GISTs with exon 11 KIT mutation.
ISSN: 0939-4451
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Clinical Genetics Section (-)
Translational Cell & Tissue Research
Department of Oncology - miscellaneous
Laboratory for Genetics of Malignant Disorders
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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