Title: A human phenome-interactome network of protein complexes implicated in genetic disorders
Authors: Lage, Kasper ×
Karlberg, E. Olof
Storling, Zenia M
Olason, Pall I
Pedersen, Anders G
Rigina, Olga
Hinsby, Anders M
Tumer, Zeynep
Pociot, Flemming
Tommerup, Niels
Moreau, Yves
Brunak, Soren #
Issue Date: Mar-2007
Publisher: Gale Group Inc.
Series Title: Nature Biotechnology vol:25 issue:3 pages:309-316
Abstract: We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human disease to create a phenome-interactome network. This was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown complexes likely to be associated with disease. Using a phenomic ranking of protein complexes linked to human disease, we developed a Bayesian predictor that in 298 of 669 linkage intervals correctly ranks the known disease-causing protein as the top candidate, and in 870 intervals with no identified disease-causing gene, provides novel candidates implicated in disorders such as retinitis pigmentosa, epithelial ovarian cancer, inflammatory bowel disease, amyotrophic lateral sclerosis, Alzheimer disease, type 2 diabetes and coronary heart disease. Our publicly available draft of protein complexes associated with pathology comprises 506 complexes, which reveal functional relationships between disease-promoting genes that will inform future experimentation.
ISSN: 1087-0156
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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