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Title: Calculation of the renal perfusion and glomerular filtration rate from the renal impulse response obtained with MRI
Authors: Hermoye, L ×
Annet, L
Lemmerling, Philippe
Peeters, F
Jamar, F
Gianello, P
Van Huffel, Sabine
Van Beers, BE #
Issue Date: May-2004
Publisher: John wiley & sons inc
Series Title: Magnetic resonance in medicine vol:51 issue:5 pages:1017-1025
Abstract: The aim of this study was to assess the importance of deconvolution for the calculation of renal perfusion and glomerular filtration rate (GFR) on the basis of concentration-time curves as measured with perfusion MRI. Six rabbits were scanned dynamically after injection of a gadolinium chelate. Concentration-time curves were generated by manually drawing regions of interest in the aorta and the renal cortex. To remove the dependency on the arterial input function, a regularized structured total least-squares deconvolution algorithm was used to calculate the renal impulse response. This curve was fitted by the sum of two gamma variate functions, corresponding to the passage of the contrast agent in the glomeruli and the proximal convoluted tubules. Tracer kinetics models were applied to these two functions to obtain the renal perfusion and GFR. For comparison, these two parameters were also calculated on the basis of the renal concentration-time curve before deconvolution. The renal perfusion values correlated well (r = 0.9, P = 0.014) with the values calculated by a validated upslope method. The GFR values correlated well (r = 0.9, P = 0.014) with the values obtained from the clearance of Cr-51-EDTA. A comparison of the values obtained with and without deconvolution demonstrated the necessity of deconvolution. (C) 2004 Wiley-Liss, Inc.
URI: 
ISSN: 0740-3194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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