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Title: Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia
Authors: Zamani, M G ×
De Hert, Marc
Spaepen, Marijke
Hermans, M
Marynen, Peter
Cassiman, Jean-Jacques
Peuskens, Joseph #
Issue Date: May-1994
Series Title: American Journal of Medical Genetics vol:54 issue:4 pages:372-7
Abstract: In the present study the HLA-DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4*A4 allele and CD4*A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.
ISSN: 0148-7299
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
University Centre Sint Jozef (-)
Research Group Psychiatry
Forensic Biomedical Sciences
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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