Title: Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis
Authors: Timmers, Maarten *
Vekemans, Katrien *
Vermijlen, D
Asosingh, K
Kuppen, P
Bouwens, L
Wisse, E
Braet, F # ×
Issue Date: Dec-2004
Publisher: Wiley-liss
Series Title: International Journal of Cancer vol:112 issue:5 pages:793-802
Abstract: Liver sinusoids harbor populations of 2 important types of immunocompetent cells, Kupffer cells (KCs) and natural killer (NK) cells, which are thought to play an important role in controlling hepatic metastasis in the first 24 hr upon arrival of the tumor cells in the liver. We studied the early interaction of KCs, NK and CC531s colon carcinoma cells in a syngeneic rat model by confocal laser scanning microscopy. Results showed a minority of KCs (19% periportal and 7% pericentral) involved in the interaction with 94% of tumor cells and effecting the phagocytosis of 92% of them. NK cell depletion decreased the phagocytosis of tumor cells by KCs by 33% over a period of 24 hr, leaving 35% of the cancer cells free, as compared to 6% in NK-positive rats. Surviving cancer cells were primarily located close to the Glisson capsule, suggesting that metastasis would initiate from this region. (C) 2001 Wiles-Liss, Inc.
ISSN: 0020-7136
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
* (joint) first author
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science