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Title: The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
Authors: Comijn, J ×
Berx, G
Vermassen, P
Verschueren, Kristin
Van Grunsven, Leonardus
Bruyneel, E
Mareel, M
Huylebroeck, Danny
van Roy, F #
Issue Date: Jun-2001
Series Title: Molecular cell. vol:7 issue:6 pages:1267-78
Abstract: Transcriptional downregulation of E-cadherin appears to be an important event in the progression of various epithelial tumors. SIP1 (ZEB-2) is a Smad-interacting, multi-zinc finger protein that shows specific DNA binding activity. Here, we report that expression of wild-type but not of mutated SIP1 downregulates mammalian E-cadherin transcription via binding to both conserved E2 boxes of the minimal E-cadherin promoter. SIP1 and Snail bind to partly overlapping promoter sequences and showed similar silencing effects. SIP1 can be induced by TGF-beta treatment and shows high expression in several E-cadherin-negative human carcinoma cell lines. Conditional expression of SIP1 in E-cadherin-positive MDCK cells abrogates E-cadherin-mediated intercellular adhesion and simultaneously induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors.
URI: 
ISSN: 1097-2765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Biology (Celgen) (-)
× corresponding author
# (joint) last author

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