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Title: Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes
Authors: Willems, Jean ×
Noppe, W
Moerman, Leentje
van der Walt, J
Verdonck, Alfons #
Issue Date: Dec-2002
Publisher: Pergamon-elsevier science ltd
Series Title: Toxicon vol:40 issue:12 pages:1679-1683
Abstract: We have isolated two cationic peptides, sharing partial homology with each other, from the venom of South African scorpions. Both synthetic peptides-one containing 44 amino acids, the other containing 45 amino acids-were constructed. At submicromolar concentrations they can activate granulocytes as evidenced by a concentration dependent chemotaxis and exocytosis. They also strongly inhibit the production of superoxide anions. At higher concentrations they act as pore formers and induce leakage of the cells. These different effects may be related to their amphipathic structure. (C) 2002 Elsevier Science Ltd. All rights reserved.
ISSN: 0041-0101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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