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Title: Rearrangement of immunoglobulin and TCR genes in lymphoid blast crisis of Ph+ chronic myeloid leukaemia
Authors: Kerim, S ×
Stul, Michel
Mecucci, Christina
Vandenberghe, E
Cuneo, A
Dal Cin, Paola
Michaux, J L
Louwagie, Andries
Cassiman, Jean-Jacques
Van den Berghe, Herman #
Issue Date: Jul-1990
Series Title: British Journal of Haematology vol:74 issue:4 pages:414-9
Abstract: Clonal rearrangements of immunoglobulin heavy chain genes as well as both T cell receptor (TCR) delta and gamma genes were found in four cases of blast crisis of Ph+ chronic myeloid leukaemia with unequivocal B cell precursor (common) immunophenotype. In one case, the TCR beta chain gene was also rearranged. Although the developmental sequence of TCR delta, gamma and beta rearrangements in T lymphocytes appeared to be respected, a full phenotypic effect, characteristic of T cell was not observed in these otherwise typical 'common' blast cells. Cytogenetic analysis ruled out the occurrence of TCR rearrangement due to structural chromosome changes. A high incidence of unexpected TCR gene rearrangements has been previously reported in the de novo 'common' acute lymphoblastic leukaemias (ALL). Our cases of chronic myeloid leukaemia (CML) in lymphoid blast crisis show that genotypic similarities may exist between these two haematological entities.
ISSN: 0007-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
Forensic Biomedical Sciences
Clinical Genetics
× corresponding author
# (joint) last author

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