Title: External validation of mathematical models to distinguish between benign and malignant adnexal tumors: A multicenter study by the International Ovarian Tumor Analysis group
Authors: Van Holsbeke, Caroline ×
Van Calster, Ben
Valentin, Lil
Testa, Antonia C
Ferrazzi, Enrico
Dimou, Ioannis
Lu, Chuan
Moerman, Philippe
Van Huffel, Sabine
Vergote, Ignace
Timmerman, Dirk #
Issue Date: Aug-2007
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:13 issue:15 pages:4440-4447
Abstract: PURPOSE: Several scoring systems have been developed to distinguish between benign and malignant adnexal tumors. However, few of them have been externally validated in new populations. Our aim was to compare their performance on a prospectively collected large multicenter data set. EXPERIMENTAL DESIGN: In phase I of the International Ovarian Tumor Analysis multicenter study, patients with a persistent adnexal mass were examined with transvaginal ultrasound and color Doppler imaging. More than 50 end point variables were prospectively recorded for analysis. The outcome measure was the histologic classification of excised tissue as malignant or benign. We used the International Ovarian Tumor Analysis data to test the accuracy of previously published scoring systems. Receiver operating characteristic curves were constructed to compare the performance of the models. RESULTS: Data from 1,066 patients were included; 800 patients (75%) had benign tumors and 266 patients (25%) had malignant tumors. The morphologic scoring system used by Lerner gave an area under the receiver operating characteristic curve (AUC) of 0.68, whereas the multimodal risk of malignancy index used by Jacobs gave an AUC of 0.88. The corresponding values for logistic regression and artificial neural network models varied between 0.76 and 0.91 and between 0.87 and 0.90, respectively. Advanced kernel-based classifiers gave an AUC of up to 0.92. CONCLUSION: The performance of the risk of malignancy index was similar to that of most logistic regression and artificial neural network models. The best result was obtained with a relevance vector machine with radial basis function kernel. Because the models were tested on a large multicenter data set, results are likely to be generally applicable.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Basic Research in Gynaecology Section (-)
Gynaecological Imaging Section (-)
Gynaecological Oncology
Translational Cell & Tissue Research
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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