Transcranial magnetic motor evoked-potentials in sedated dogs
Vanham, Lml × Vanderstraeten, Ggw Mattheeuws, Drg Nijs, Johan #
Veterinary practice publ co
Progress in veterinary neurology vol:5 issue:4 pages:147-154
Transcranial magnetic motor evoked potentials (TMMEP) were obtained in normal sedated dogs. Forms of sedation evaluated were (1) xylazine and methadone, (2) acepromazine and methadone, (3) medetomidine and methadone, and (4) droperidol and fentanyl. Stimuli were delivered first with the current in the coil flowing in counter-clockwise direction, then with the current in the coil flowing in clockwise direction. TMMEP were recorded from the extensor carpi radialis muscles of the thoracic limbs and from the cranial tibial muscles of the pelvic limbs. Onset latencies and peak-to-peak amplitudes of the TMMEP were compared for the four forms of sedation to see which drug combination allowed a recording of TMMEP with the shortest latencies and the highest amplitudes. Onset latencies and peak-to-peak amplitudes of the TMMEP were also compared to see if there were differences between stimulation with the current in the coil flowing in counter-clockwise or in clockwise direction. All forms of sedation allowed recording of TMMEP. Droperidol and fentanyl and acepromazine and methadone sedation were considered superior to xylazine and methadone and to medetomidine and methadone, because they produced TMMEP with significantly shorter latencies (droperidol and fentanyl only) and significantly higher amplitudes (both droperidol and fentanyl and acepromazine and methadone). No differences were found between stimulation with the current in the coil flowing in counter-clockwise or in clockwise direction.