Title: Genetic "clocks" and "soft" events: A twin model for pubertal development and other recalled sequences of developmental milestones, transitions, or ages at onset
Authors: Pickles, A ×
Pickering, K
Simonoff, E
Silberg, J
Meyer, J
Maes, Hermine #
Issue Date: Jul-1998
Publisher: Plenum publ corp
Series Title: Behavior genetics vol:28 issue:4 pages:243-253
Abstract: We propose and explore a twin model to examine the basis for synchrony that often characterizes different facets of normal development. In so doing we also present an approach to the analysis of "soft" events; events for which available reports of dates or ages of occurrence are unreliable or inconsistent. Discrepancies among reports are accounted for by a statistical measurement model. This combines current status error reflecting uncertain definition of onset and two mechanisms for the phenomenon of "telescoping," namely, systematic compression of the time scale and heteroscedastic random measurement error. Statistically, the model can be viewed as a mixed generalized linear model with random effects within both mean and variance functions or, alternatively, as involving multiplicative random effects. We apply the model to multiple maternal reports on menarche and onset of breast development in twin daughters. Fitted to data from the Virginia Twin Study Of Adolescent and Behavioral Development by the use of penalized/predictive quasi-likelihood, the model provided much improved estimates of the true age-at-onset distribution as compared to those from a naive analysis. Results suggested that the observed variance was made up almost entirely of genetic variance and measurement error variance due to telescoping and current status errors and that the timing of breast development and menarche are largely under the control of a common set of genes. Results also indicated that maternal recollections of the onset of breast development were both more poorly defined and subject to greater recall errors than maternal recollections of menarche.
ISSN: 0001-8244
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Neurophysiology
Exercise Physiology Research Group
Teacher Training, Faculty of Kinesiology and Rehabilitation Sciences
× corresponding author
# (joint) last author

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