Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers
De Smet, M × Schoors, DF DeMeyer, G Verbesselt, René Goldberg, MR Fitzpatrick, V Somers, G #
Blackwell science ltd
British journal of clinical pharmacology vol:40 issue:6 pages:571-575
1 Losartan (DuP 753, MK-954) is a novel, potent and highly selective AT(1) angiotensin II receptor antagonist. The effect of multiple oral doses of losartan on digoxin pharmacokinetics was evaluated in healthy male subjects.