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Title: Evaluation of signal-processing methods for the quantification of strongly overlapping peaks in p-31 nmr-spectra
Authors: Decanniere, C ×
Van Hecke, Paul
Vanstapel, Florent
Chen, H
Van Huffel, Sabine
Vandervoort, C
Vantongeren, B
Vanormondt, D #
Issue Date: Sep-1994
Publisher: Academic press inc jnl-comp subscriptions
Series Title: Journal of magnetic resonance series b vol:105 issue:1 pages:31-37
Abstract: A time series of 16 P-31 NMR spectra of rat liver perfused with 2,5-anhydro-D-mannitol has been quantitatively analyzed by two types of model function fitting algorithms in the time domain: an iterative least-squares fitting procedure (VARPRO) and a noniterative singular-value-decomposition-based method, combined with minimum-variance preprocessing (MV-HTLS). MV-HTLS, which does not allow the incorporation of prior knowledge, is unreliable for the quantification of overlapping peaks at low signal-to-noise ratio. Although the overall fit is good, i.e., the residue is small, the fitted parameters do not accurately represent the individual components. The incorporation of prior knowledge about the model parameters results in a significant gain in precision of VARPRO. (C) 1994 Academic Press, Inc.
URI: 
ISSN: 1064-1866
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomedical MRI
Laboratory of Clinical Bacteriology and Mycology
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Biomedical Quality Assurance Research Unit
× corresponding author
# (joint) last author

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