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Title: Evaluation of two unstructured mathematical-models for the penicillin-g fed-batch fermentation
Authors: Nicolai, Bart ×
Van Impe, Jan
Vanrolleghem, Peter
Vandewalle, Joos #
Issue Date: Nov-1992
Publisher: Kluwer academic publ
Series Title: Antonie van leeuwenhoek international journal of general and molecular microbiology vol:62 issue:4 pages:273-283
Abstract: The mathematical model for the penicillin G fed-batch fermentation proposed by Heijnen et al. (1979) is compared with the model of Bajpai & Reuss (1980). Although the general structure of these models is similar, the difference in metabolic assumptions and specific growth and production kinetics results in a completely different behaviour towards product optimization. A detailed analysis of both models reveals some physical and biochemical shortcomings. It is shown that it is impossible to make a reliable estimation of the model parameters, only using experimental data of simple constant glucose feed rate fermentations with low initial substrate amount. However, it is demonstrated that some model parameters might be key factors in concluding whether or not altering the substrate feeding strategy has an important influence on the final amount of product.
ISSN: 0003-6072
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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