Title: The effect of mk-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in-vivo
Authors: Diamant, Z
Timmers, Mc
Vanderveen, H
Friedman, Bs
De Smet, M
Depré, Marleen
Hilliard, D
Bel, Eh
Sterk, Pj #
Issue Date: Jan-1995
Publisher: Mosby-year book inc
Series Title: Journal of allergy and clinical immunology vol:95 issue:1 pages:42-51
Abstract: Background: The 5-lipoxygenase metabolites of arachidonic acid are likely to be involved in the pathophysiology of atopic asthma. We investigated the effect of pretreatment with MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on allergen-induced early asthmatic reactions (EARs) and late asthmatic reactions (LARs), and subsequent airway hyperresponsiveness to histamine.
ISSN: 0091-6749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Pharmacology Centre (-)
# (joint) last author

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