The effect of mk-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in-vivo
Diamant, Z Timmers, Mc Vanderveen, H Friedman, Bs De Smet, M Depré, Marleen Hilliard, D Bel, Eh Sterk, Pj #
Mosby-year book inc
Journal of allergy and clinical immunology vol:95 issue:1 pages:42-51
Background: The 5-lipoxygenase metabolites of arachidonic acid are likely to be involved in the pathophysiology of atopic asthma. We investigated the effect of pretreatment with MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on allergen-induced early asthmatic reactions (EARs) and late asthmatic reactions (LARs), and subsequent airway hyperresponsiveness to histamine.