Title: TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
Authors: Cuypers, Eva ×
Yanagihara, A.
Rainier, J.D.
Tytgat, Jan #
Issue Date: Sep-2007
Publisher: Academic Press
Series Title: Biochemical and Biophysical Research Communications vol:361 issue:1 pages:214-217
Abstract: Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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