Title: Formation of angiotensin-(1-7) from angiotensin II by the venom of Conus geographus
Authors: Le, Minh Tam ×
Vanderheyden, Patrick M L
Baggerman, Geert
Vanden Broeck, Jozef
Vauquelin, Georges #
Issue Date: 15-Apr-2002
Publisher: Elsevier/North-Holland
Series Title: Regulatory Peptides vol:105 issue:2 pages:101-108
Abstract: The binding of [3H]angiotensin II to AT(1) receptors on Chinese Hamster Ovary cells expressing the human AT(1) receptor (CHO-AT(1) cells) is potently inhibited by venoms of the marine snails Conus geographus and C. betulinus. On the other hand, the binding of the nonpeptide AT(1) receptor-selective antagonist [3H]candesartan is not affected but competition binding curves of angiotensin II and the peptide antagonist [Sar(1),Ile(8)]angiotensin II (sarile) are shifted to the right. These effects resulted from the breakdown of angiotensin II into smaller fragments that do not bind to the AT(1) receptor. In this context, angiotensin-(1-7) is the most prominent fragment and angiotensin-(1-4) and angiotensin-(1-5) are also formed but to a lesser extent. The molecular weight of the involved peptidases exceeds 50 kDa, as determined by gel chromatography and ultrafitration.
ISSN: 0167-0115
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Microbial and Molecular Systems - miscellaneous
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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