Title: Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands
Authors: Van Loy, Tom ×
Vandersmissen, Hans Peter
Van Hiel, Matthias
Poels, Jeroen
Verlinden, Heleen
Badisco, Liesbeth
Vassart, Gilbert
Vanden Broeck, Jozef #
Issue Date: 2008
Publisher: Academic Press
Series Title: General and Comparative Endocrinology vol:155 issue:1 pages:14-21
Abstract: Leucine-rich repeats containing G protein-coupled receptors (LGRs) constitute a unique cluster of transmembrane proteins sharing a large leucine-rich extracellular domain for hormone binding. In mammals, LGRs steer important developmental, metabolic and reproductive processes as receptors for glycoprotein hormones and insulin/relaxin-related proteins. In insects, a receptor structurally related to human LGRs mediates the activity of the neurohormone bursicon thereby regulating wing expansion behaviour and remodelling of the newly synthesized exoskeleton. In the past decade, novel insights into the molecular evolution of LGR encoding genes accumulated rapidly due to comparative genome analyses indicating that the endocrine LGR signalling system likely emerged before the radiation of metazoan phyla and expanded throughout evolution. Here, we present a short survey on the evolution of LGRs and the hormones they interact with.
ISSN: 0016-6480
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Research Group Molecular Developmental Physiology and Signal Transduction (-)
× corresponding author
# (joint) last author

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