Title: Dracunculus medinensis and Schistosoma mansoni contain opiate alkaloids
Authors: Zhu, W ×
Baggerman, Geert
Secor, W Evan
Casares, F
Pryor, S C
Fricchione, G L
Ruiz-Tiben, E
Eberhard, M L
Bimi, L
Stefano, G B #
Issue Date: Mar-2002
Series Title: Annals of tropical medicine and parasitology vol:96 issue:3 pages:309-16
Abstract: The results of analysis, by high-performance liquid chromatography coupled with electrochemical detection and by nano-electrospray-ionization, double quadrupole/orthogonal-acceleration, time-of-flight mass spectrometry, indicate that adult Dracunculus medinensis and Schistosoma mansoni both contain the opiate alkaloid morphine and that D. medinesis also contains the active metabolite of morphine, morphine 6-glucuronide. From these and previous observations, it would appear that many helminths are probably using opiate alkaloids as potent immunosuppressive and antinociceptive signal molecules, to down-regulate immunosurveillance responsiveness and pain signalling in their hosts.
ISSN: 0003-4983
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Microbial and Molecular Systems - miscellaneous
× corresponding author
# (joint) last author

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