Title: Behavioural and physiological effects of electrical stimulation in the nucleus accumbens: a review
Authors: van Kuyck, Kris
Gabriƫls, Lutgardis
Cosyns, P
Arckens, Lut
Sturm, V
Rasmussen, S
Nuttin, Bart
Issue Date: 2007
Publisher: Springer Wien
Host Document: Operative Neuromodulation. Volume 2: Neural Networks Surgery pages:375-391
Abstract: Electrical stimulation (ES) in the brain is becoming a new treatment option in patients with treatment-resistant obsessive-compulsive disorder (OCD). A possible brain target might be the nucleus accumbens (NACC). This review aims to summarise the behavioural and physiological effects of ES in the NACC in humans and in animals and to discuss these findings with regard to neuroanatomical, electrophysiological and behavioural insights. The results clearly demonstrate that ES in the NACC has an effect on reward, activity, fight-or-flight, exploratory behaviour and food intake, with evidence for only moderate physiological effects. Seizures were rarely observed. Finally, the results of ES studies in patients with treatment-resistant OCD and in animal models for OCD are promising.
ISBN: 978-3-211-33080-7
ISSN: 0065-1419
VABB publication type: VABB-4
Publication status: published
KU Leuven publication type: IHb
Appears in Collections:Research Group Experimental Neurosurgery and Neuroanatomy
Animal Physiology and Neurobiology Section - miscellaneous
Research Group Psychiatry

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