Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cell Biology, Developmental Biology, FATTY-ACID SYNTHASE, COA-DESATURASE 1, ATP-CITRATE LYASE, METASTASIS-INITIATING CELLS, THERAPEUTIC TARGET, COLORECTAL-CANCER, LUNG-CANCER, TUMOR MICROENVIRONMENT, MEVALONATE PATHWAY, SUPPRESSOR-CELLS, cancer, immunometabolism, lipids, metabolism, metastasis, tumor microenvironment, Animals, Diet, Ferroptosis, Humans, Lipid Metabolism, Neoplasms, Signal Transduction, Tumor Microenvironment, G098120N#55518322, 06 Biological Sciences, 11 Medical and Health Sciences, 3101 Biochemistry and cell biology

Abstract:

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. As such, targeting lipid metabolism for anti-cancer therapies is attractive, with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. Here, we discuss these topics and identify open questions.