Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, PREDICTS POOR-PROGNOSIS, PROMOTES TUMOR-METASTASIS, FATTY-ACID OXIDATION, SERUM-LIPID PROFILE, HEPATOCELLULAR-CARCINOMA, PYRUVATE-CARBOXYLASE, MONOCARBOXYLATE TRANSPORTER, REDOX HOMEOSTASIS, EXOGENOUS LIPIDS, INITIATING CELLS, Acetates, Adenosine Triphosphate, Animals, Cell Plasticity, Fatty Acids, Glutamine, Humans, Lactic Acid, Neoplasm Metastasis, Neoplasms, Neoplastic Cells, Circulating, Pyruvic Acid, G098120N#55518322, 11 Medical and Health Sciences, Oncology & Carcinogenesis, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is still an unresolved challenge. Only recently, attention has been drawn to the fact that metastasizing cancer cells selectively and dynamically adapt their metabolism at every step during the metastatic cascade. Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment. Consequently, the stage-dependent metabolic traits may provide therapeutic windows for preventing or reducing metastasis, and targeting the new metabolic traits arising in established metastases may allow their eradication.