An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age

Vermeulen, Isabel; Weets, I; Costa, O; Asanghanwa, M; Verhaeghen, K; Decochez, K; Ruige, J; Casteels, Kristina; Wenzlau, J; Hutton, JC; Pipeleers, DG; Gorus, FK; Belgian Diabetes Registry,

doi:10.1007/s00125-011-2376-1

An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age

Author:

Vermeulen, Isabel

Weets, I ; Costa, O ; Asanghanwa, M ; Verhaeghen, K ; Decochez, K ; Ruige, J ; Casteels, Kristina ; Wenzlau, J ; Hutton, JC ; Pipeleers, DG ; Gorus, FK ; Belgian Diabetes Registry,

Keywords:

Adolescent, Adult, Age Factors, Autoantibodies, Cation Transport Proteins, Child, Child, Preschool, Diabetes Mellitus, Type 1, Disease-Free Survival, Family Health, Female, Glutamate Decarboxylase, Humans, Insulin, Male, Prediabetic State, Time Factors, Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, First-degree relatives, GAD, IA-2, Prediabetes, Proinsulin, Seroconversion, Type 1 diabetes, Zinc transporter 8, CLINICAL ONSET, RISK, AUTOIMMUNITY, POPULATION, PREDICTION, ANTIBODIES, CHILDHOOD, IDDM, EPIDEMIOLOGY, PROGRESSION, Zinc Transporter 8, Belgian Diabetes Registry, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, 3202 Clinical sciences, 4206 Public health

Abstract:

The appearance of autoantibodies (Abs) before diabetes onset has mainly been studied in young children. However, most patients develop type 1 diabetes after the age of 15 years. In first-degree relatives aged under 40 years, we investigated the frequency of seroconversion to (persistent) Ab positivity, progression to diabetes and baseline characteristics of seroconverters according to age.