Author:

Keywords:

Science & Technology, Physical Sciences, Life Sciences & Biomedicine, Chemistry, Analytical, Pharmacology & Pharmacy, Chemistry, Stability, Plastic container, Sufentanil, Ropivacaine, Levobupivacaine, PORTABLE PUMP RESERVOIR, LEVOBUPIVACAINE, INFUSION, CITRATE, HYDROCHLORIDE, ROPIVACAINE, MIXTURE, GLASS, Amides, Anesthetics, Local, Bupivacaine, Double-Blind Method, Plastics, 0301 Analytical Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Analytical Chemistry, 3214 Pharmacology and pharmaceutical sciences, 3401 Analytical chemistry

Abstract:

The stability of sufentanil-ropivacaine and sufentanil-levobupivacaine solutions was evaluated during 6 months while stored at 4 °C. Containers for sufentanil-ropivacaine were syringe (made of polypropylene (PP)) and cassette (inside bag of polyvinylchloride) and for sufentanil-levobupivacaine syringe (PP) and infusion bag (inner layer of PP). A liquid chromatographic (LC) method was validated and allowed the measurement of the three analytes. Both solutions were found to be stable under the examined conditions with contents that remained close to 100 %.