Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cell Biology, Epigenome, Mitochondrial calcium, Metabolic remodelling, Myofibroblasts, Fibrosis, Calcium signalling, Animals, Calcium, Humans, Mitochondria, Models, Biological, G0C6419N#54969402, 0601 Biochemistry and Cell Biology, 0606 Physiology, 1116 Medical Physiology, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, 3208 Medical physiology

Abstract:

During development, disease or in response to changes in local environmental and/or nutrient supply, cellular metabolism is substantially remodeled. Reduced mitochondrial Ca2+ uptake was recently reported to induce metabolic remodeling, which through stimulating alterations in the epigenome causes changes in gene expression associated with fibroblast to myofibroblast differentiation.