Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Technology, Dentistry, Oral Surgery & Medicine, Engineering, Biomedical, Engineering, debridement, dental plaque, gingival bleeding on probing, Lactobacilli reuteri, peri-implantitis, probiotics, therapy, REUTERI-CONTAINING TABLETS, LOCAL-DRUG DELIVERY, CHRONIC PERIODONTITIS, PHOTODYNAMIC THERAPY, ANTIINFECTIVE THERAPY, DOUBLE-BLIND, LOZENGES, MUCOSITIS, OUTCOMES, Double-Blind Method, Humans, Lactobacillus, Peri-Implantitis, Pilot Projects, Probiotics, C24/17/086#54270821, G091218N#54518653, 0903 Biomedical Engineering, 1105 Dentistry, Dentistry, 3202 Clinical sciences, 3203 Dentistry, 4003 Biomedical engineering

Abstract:

OBJECTIVES: Examine the clinical and microbiological benefits of a dual-strain Lactobacillus reuteri probiotic on the non-surgical therapy of initial peri-implantitis. MATERIALS AND METHODS: This randomized, double-blind study targeted patients with initial peri-implantitis, that is peri-implantitis with a maximum mean probing pocket depth of 6 mm and maximum 3 mm bone loss compared with loading. A full-mouth prophylaxis was performed and the peri-implantitis sites were debrided. Subsequently, local application of the study drops was carried out at the peri-implantitis sites and the study lozenges were handed out. The patients in the probiotic group received drops and lozenges containing L. reuteri (ATCC PTA 5289 & DSM 17938), those in the control group received placebo products. At the implant level the measurements of interest were bleeding, probing pocket depth and plaque. Full-mouth bleeding and plaque scores were also recorded. Microbiological samples were taken from the tongue, saliva and subgingivally around the implants. RESULTS: All clinical parameters were significantly decreased after 12 and 24 weeks. At the implant level the only statistically significant difference was a greater decrease in plaque levels in the probiotic versus the control group (p = .002 at 24 weeks). At the full-mouth level, the only intergroup difference was the greater decrease in full-mouth bleeding on probing sites in the probiotic group compared with the control group (p < .001 at 24 weeks). Concerning the microbiological outcomes, no significant differences could be found at any time point, neither intra- nor intergroup. CONCLUSIONS: No adjunctive effects of the use of L. reuteri probiotics in the treatment of peri-implantitis were found.