Title: Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18(+)Escherichia coli infection
Authors: Verdonck, F ×
Tiels, P
van Gog, K
Goddeeris, Bruno
Lycke, N
Clements, J
Cox, E #
Issue Date: Dec-2007
Publisher: Elsevier science bv
Series Title: Veterinary immunology and immunopathology vol:120 issue:3-4 pages:69-79
Abstract: Post-weaning diarrhoea and oedema disease in weaned piglets are caused by infection with F4(+) or F18(+)Escherichia coli strains. There is no commercial vaccine available, but it is shown that oral immunization of weaned piglets with purified F4 fimbriae induces a protective mucosal immune response. In the present study, piglets were orally and nasally immunized with purified F18 fimbriae in the presence of the mucosal adjuvant LT(R192G) or CTA1-DD, respectively. This immunization could not lead to protection against F18(+)E. coli infection. The induced F18-specific immune response was directed towards the major subunit FedA and weakly towards the adhesive subunit FedF. The results of these experiments demonstrate that it is difficult to induce protective immunity against F18+ E. coli using the whole fimbriae due to the low response against the adhesin.
ISSN: 0165-2427
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Verdonck 2007 Vet Immunol.pdf Published 553KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science