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Title: Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Authors: Mayer, K ×
Schüller, C
Wambutt, R
Murphy, G
Volckaert, Guido
Pohl, T
Düsterhöft, A
Stiekema, W
Entian, K D
Terryn, N
Harris, B
Tacon, D
Jesse, T
Heijnen, L
Rieger, M
Schwarz, S
Scholler, P
Heber, S
Francs, P
Bielke, C
Nelson, J
Ramsperger, U
Frishman, D
Haase, D
Lemcke, K
Mewes, H W
Stocker, S
Weichselgartner, M
Zaccaria, P
Bevan, M
Wilson, R K
de la Bastide, M
Hilbert, H
Müller, M
Habermann, K
Parnell, L
Dedhia, N
Gnoj, L
Schutz, K
Huang, E
de Simone, V
Spiegel, L
Sehkon, M
Braun, M
Murray, J
Müller-Auer, S
Sheet, P
Cordes, M
Abu-Threideh, J
Stoneking, T
Kalicki, J
Graves, T
Harmon, G
Obermaier, B
Holzer, E
Edwards, J
Latreille, P
Spieth, J
Courtney, L
Cloud, J
Abbott, A
Scott, K
Johnson, D
Minx, P
Bentley, D
Brandt, A
Fulton, B
Mache, R
Miller, N
Ryan, E
Andrews, S
Geisel, C
Layman, D
Du, H
Ali, J
Berghoff, A
Peters, S
Jones, K
Drone, K
Gabel, C
Kreis, M
Cotton, M
Joshu, C
Antonoiu, B
Zidanic, M
Strong, C
Sun, H
van Staveren, M
Lamar, B
Yordan, C
Ma, Pingsheng
Fuchs, M
Zhong, J
Delseny, M
Preston, R
Vil, D
Shekher, M
Matero, A
Dirske, W
Shah, R
Swaby, I K
O'Shaughnessy, A
Rodriguez, M
Fartmann, B
Hoffmann, J
Till, S
Puigdomenech, P
Granat, S
Shohdy, N
Mooijman, P
Hasegawa, A
Hameed, A
Lodhi, M
Johnson, A
Chen, E
Granderath, K
Marra, M
Martienssen, R
McCombie, W R
Watson, M
Argiriou, A
Schmidtheini, T
Reichert, B
Portatelle, D
Perez-Alonso, M
Boutry, M
Bancroft, I
Dauner, D
Vos, P
Hoheisel, J
Zimmermann, W
Greco, T
Wedler, H
Ridley, P
Langham, S A
McCullagh, B
Bilham, L
Robben, Johan
Van der Schueren, J
Herzl, A
Grymonprez, B
Chuang, Yi-Chen
Klein Lankhorst, R
Vandenbussche, Frank
Braeken, M
Weltjens, I
Voet, M
Bastiaens, I
Aert, Rita
Defoor, E
Weitzenegger, T
Neumann, S
Bothe, G
Rose, M
Hauf, J
Kötter, P
Berneiser, S
Hempel, S
Feldpausch, M
Lamberth, S
Van den Daele, H
De Keyser, A
Kemp, K
Vitale, D
Buysshaert, C
Gielen, J
Villarroel, R
De Clercq, R
Van Montagu, M
Rogers, J
Cronin, A
Quail, M
Bray-Allen, S
Kramer, J
Clark, L
Ansorge, W
Doggett, J
Hall, S
Kay, M
Lennard, N
McLay, K
Mayes, R
Pettett, A
Rajandream, M A
Fulton, L
Lyne, M
Benes, V
Liguori, R
Rechmann, S
Borkova, D
Blöcker, H
Scharfe, M
Grimm, M
Löhnert, T H
Dose, S
Mardis, E
de Haan, M
Maarse, A
Schäfer, M
Piravandi, E
Massenet, O
Quigley, F
Clabauld, G
Mündlein, A
Felber, R
Schnabl, S
Dante, M
Hiller, R
Schmidt, W
Brandt, P
Lecharny, A
Aubourg, S
Chefdor, F
Cooke, R
Berger, C
Montfort, A
Casacuberta, E
Pepin, K
Gibbons, T
Weber, N
Vandenbol, M
Grivell, L
Bargues, M
Terol, J
Torres, A
Perez-Perez, A
Purnelle, B
Bent, E
Hillier, L
Johnson, S #
Issue Date: 16-Nov-1999
Series Title: Nature vol:402 issue:6763 pages:769-77
Abstract: The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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