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Title: Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart
Authors: Heymans, Stephane
Schroen, B
Vermeersch, Pieter
Milting, H
Gao, FY
Kassner, A
Gillijns, Hilde
Herijgers, Paul
Flameng, Willem
Carmeliet, Peter
de Werf, FV
Pinto, YM
Janssens, Stefan #
Issue Date: Aug-2005
Publisher: Lippincott williams & wilkins
Series Title: Circulation vol:112 issue:8 pages:1136-1144
Abstract: Background - Alterations in the balance of matrix metalloproteinases ( MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload - induced LV hypertrophy, however, is unknown.
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Clinical Residents Medicine
Vesalius Research Centre (-)
Molecular and Vascular Biology
Experimental Cardiac Surgery (-)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
# (joint) last author

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