Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Coronary disease, endothelium, exercise, cardiac rehabilitation, polymorphism, oxygen uptake, PEAK EXERCISE CAPACITY, NITRIC-OXIDE, PHYSICAL-ACTIVITY, EXPRESSION, POLYMORPHISM, MODULATION, GENOTYPE, Catalase, Coronary Artery Disease, Endothelium, Vascular, Exercise Tolerance, Female, Glutathione Peroxidase, Humans, Male, Middle Aged, NADPH Oxidases, Nitric Oxide Synthase Type III, Oxygen Consumption, PPAR alpha, Polymorphism, Genetic, Superoxide Dismutase, Vascular Endothelial Growth Factor A, Glutathione Peroxidase GPX1, NITRIC-OXIDE SYNTHASE, CARDIOVASCULAR-DISEASE, HEART-FAILURE, NO SYNTHASE, POPULATION, 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, 3201 Cardiovascular medicine and haematology

Abstract:

Aerobic phenotypes show a wide variability to similar aerobic training stimuli, which can be partly attributed to heritability. Endothelial function affects aerobic power. Various physiological pathways may influence the endothelial function. Therefore, we aimed to examine whether polymorphisms of the eNos gene, the CAT gene, the VEGF gene, the GPX1 gene, the subunit P22 phox of the NAD(P)H-odixase gene, the PPAR-alpha gene, and the PGC-alpha gene are associated with aerobic power or with its response to physical training in patients with coronary artery disease (CAD).