Title: Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa
Authors: Cox, E ×
Verdonck, F
Vanrompay, Daisy
Goddeeris, Bruno #
Issue Date: May-2006
Publisher: Edp sciences s a
Series Title: Veterinary research vol:37 issue:3 pages:511-539
Abstract: In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins ( cholera toxin, LT enterotoxin, their B subunits and mutants); ( 2) surface immunoglobulin binding complex CTA1-DD; (3) TLR4 binding lipopolysaccharide; (4) TLR2-binding muramyl dipeptide; (5) Mannose receptor-binding mannan; (6) Dectin-1-binding beta 1,3/1,6 glucans; (7) TLR9-binding CpG-oligodeoxynucleotides; (8) Cytokines and chemokines; (9) Antigen-presenting cell targeting ISCOMATRIX and ISCOM. In addition, attention is given to two adjuvants able to prime the mucosal immune system following a systemic immunization, namely 1 alpha, 25(OH)(2)D-3 and cholera toxin.
ISSN: 0928-4249
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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