Author:

Keywords:

Science & Technology, Physical Sciences, Life Sciences & Biomedicine, Chemistry, Applied, Chemistry, Medicinal, Chemistry, Pharmacology & Pharmacy, Endolichenic fungus, Parmotrema ravum, Aspergillus niger, aspergyllone, antimicrobial activity, NAPHTHO-GAMMA-PYRONES, CONVENIENT SYNTHESIS, FUNGUS, DERIVATIVES, Anti-Bacterial Agents, Anti-Infective Agents, Antifungal Agents, Chromones, Drug Evaluation, Preclinical, Humans, India, Inhibitory Concentration 50, Lichens, Parmeliaceae, Phenylalanine, Pyrones, Medicinal & Biomolecular Chemistry

Abstract:

A new 6-benzyl-γ-pyrone (1), named aspergyllone was isolated from the culture filtrates of an endolichenic fungus Aspergillus niger Tiegh, obtained from lichen thallus Parmotrema ravum (Krog & Swinscow) Serus, collected in India. 1 was isolated for the first time from an endolichenic fungus together with six other known metabolites identified as aurasperones A (2) and D (3), asperpyrone A (4), fonsecinone A (5), carbonarone A (6) and pyrophen (7). The compounds were tested against a panel of human, plant, food borne and fish pathogens. Aspergyllone showed strong selective antifungal activity against Candida parapsilosis (Ashford) Langeron & Talice, with an IC50 of 52 µg/mL. Aurasperone A and pyrophen showed moderate to strong antimicrobial activity inhibiting seven different test pathogens, being pyrophen active with IC50 ranging from 35 to 97 µg/mL.[Formula: see text].