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Title: Soluble guanylate cyclase-alpha 1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia
Authors: Vermeersch, Pieter ×
Buys, Emmanuel
Pokreisz, Peter
Marsboom, Glenn
Ichinose, Fumito
Sips, Patrick
Pellens, Marijke
Gillijns, Hilde
Swinnen, Marc
Graveline, Amanda
Collen, Desire
Dewerchin, Mieke
Brouckaert, Peter
Bloch, Kenneth D
Janssens, Stefan #
Issue Date: Aug-2007
Publisher: Lippincott williams & wilkins
Series Title: Circulation vol:116 issue:8 pages:936-943
Abstract: Background - Nitric oxide ( NO) activates soluble guanylate cyclase (sGC), a heterodimer composed of alpha- and beta-subunits, to produce cGMP. NO reduces pulmonary vascular remodeling, but the role of sGC in vascular responses to acute and chronic hypoxia remains incompletely elucidated. We therefore studied pulmonary vascular responses to acute and chronic hypoxia in wild-type (WT) mice and mice with a nonfunctional alpha 1-subunit (sGC alpha 1(-/-)).
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Clinical Residents Medicine
Experimental Cardiology
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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