Title: Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients
Authors: Dumont, D ×
Noben, JP
Raus, J
Stinissen, P
Robben, Johan #
Issue Date: Jul-2004
Publisher: Wiley-v c h verlag gmbh
Series Title: Proteomics vol:4 issue:7 pages:2117-2124
Abstract: Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system. Disease mechanisms in multiple sclerosis at the molecular level remain poorly understood and no reliable proteinaceous disease markers are available yet. The goal of the present study is the construction of a protein database of two-dimensional gel electrophoresis (2-DE) separated cerebrospinal fluid (CSF) proteins from multiple sclerosis patients. By means of liquid chromatography tandem mass spectrometry 65 different proteins were identified from 300 spots. Eighteen of these proteins have not been reported previously on 2-DE gels of CSF Here we report on the identification of these proteins and discuss their potential relation to multiple sclerosis.
ISSN: 1615-9853
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science