Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Medicine, Research & Experimental, Otorhinolaryngology, Research & Experimental Medicine, Chronic rhinosinusitis, nasal polyps, endoscopic sinus surgery, intranasal corticosteroids, montelukast, ENDOSCOPIC SINUS SURGERY, LEUKOTRIENE RECEPTOR ANTAGONIST, ASTHMA, MANAGEMENT, GA(2)LEN, COLLABORATION, RHINITIS, UPDATE, EUROPE, Acetates, Administration, Intranasal, Adrenal Cortex Hormones, Adult, Aged, Chronic Disease, Cyclopropanes, Drug Therapy, Combination, Endoscopy, Female, Follow-Up Studies, Humans, Leukotriene Antagonists, Male, Middle Aged, Nasal Polyps, Paranasal Sinuses, Postoperative Period, Prospective Studies, Quinolines, Rhinitis, Sinusitis, Sulfides, Treatment Outcome, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add-on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking.