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Title: Formation of delta-2-cholenoic and delta-3-cholenoic acids from bile-acid 3-sulfates by a human intestinal fusobacterium strain
Authors: Robben, Johan
Janssen, Gerardus
Merckx, R
Eyssen, Hendrik #
Issue Date: Nov-1989
Publisher: Amer soc microbiology
Series Title: Applied and Environmental Microbiology vol:55 issue:11 pages:2954-2959
Abstract: We isolated two strains of an unnamed Fusobacterium species from human intestinal microflora, which stereospecifically transformed bile acid 3-sulfates into C-3-unsubstituted, ring A-unsaturated bile acids. Both 3 alpha- and 3 beta-sulfates of 5 beta-bile acids were metabolized to delta 3-5 beta-cholenoic acids; 3 beta-sulfates of 5 alpha-bile acids were converted into a mixture of delta 2-5 alpha-bile acids and 3 alpha-hydroxy-5 alpha-bile acids, whereas 3 alpha-sulfates of 5 alpha-bile acids were left intact. Unsulfated bile acids were not transformed into unsaturated derivatives. These strains differ from previously isolated intestinal bacteria, which desulfated bile acid sulfates without further transformation.
ISSN: 0099-2240
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
Medicinal Chemistry (Rega Institute)
# (joint) last author

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