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Title: Dose-response relationships between dietary (n-3) fatty-acids and plasma and tissue-lipids, steroid-excretion and urinary malondialdehyde in rats
Authors: De Schrijver, Remi ×
Vermeulen, D
Daems, V #
Issue Date: Oct-1992
Publisher: Amer inst nutrition
Series Title: The Journal of Nutrition vol:122 issue:10 pages:1979-1987
Abstract: For a 28-d experimental period, rats were fed a nonpurified, cereal-based diet containing 9.1% supplemental beef tallow or fish oil or one of the following beef tallow:fish oil blends: 95:5; 90:10; 80:20 and 50:50. All diets provided between 21.3 and 22.7 g linoleic acid/kg. Higher fish oil intake was paralleled by elevated incorporation of long-chain (n-3) fatty acids in plasma total lipid, mainly at the expense of arachidonic acid. Significant inverse relationships were found between plasma total (n-3) fatty acid concentration and plasma triglyceride, cholesterol or free fatty acid concentrations. Fish oil intake did not lead to a shift of triglycerides or cholesterol from the plasma to the tissues (liver, heart, kidneys). Reduced plasma cholesterol concentrations in the fish oil-fed rats could not be explained by higher fecal excretion of neutral sterols and bile acids. In vivo lipid peroxidation, assessed by urinary malondialdehyde excretion, was enhanced when diets containing >1.8% fish oil were fed.
ISSN: 0022-3166
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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