Title: Thyrotropin-releasing-hormone (trh) is not thyrotropic but somatotropic in fed and starved adult chickens
Authors: Kuhn, Er ×
Herremans, M
Dewil, Erna
Vanderpooten, Anita
Rudas, P
Bartha, T
Verheyen, G
Berghman, Luc
Decuypere, Eddy #
Issue Date: 1991
Publisher: Editions scientifiques elsevier
Series Title: Reproduction nutrition development vol:31 issue:4 pages:431-439
Abstract: Adult fed and starved Warren chickens, 2 yr of age, and approaching the end of the second laying year, were injected iv with 1 of the following products: 10-mu-g of thyrotropin releasing hormone (TRH); 100-mu-g of bovine thyrotropin (bTSH); 100-mu-g of ovine growth hormone (oGH); saline. The influence on plasma concentrations of thyroxine (T4), triiodothyronine (T3) or chicken GH (cGH) were followed. Prior to injection, it was clear from the control values that starvation for 3 d decreased plasma levels of T3 and increased cGH, whereas 7 d of fasting increased T4 and cGH. The plasma levels of cGH were elevated > 10-fold at 15 min following the TRH challenge in food-deprived chickens compared to a < 4-fold increase in normal fed hens. This increase was followed by a rise in T3 after 1 h, which was also more pronounced in the starved animals, whereas T4 decreased or remained unaffected. Increases in T4 can, however, be obtained with 100-mu-g TSH in normal fed (2-fold) or starved animals (> 3-fold). Following injection of 100-mu-g oGH, a significant increase in T3 levels was observed which in fed animals was already present at 30 min, but the higher levels persisted for 1 and 2 h in fed and starved hens. At the same time, a decrease in T4 was observed in both groups of GH-treated chickens. It is concluded that TRH at the dose used is not thyrotropic but has a somatotropic effect and is responsible for the peripheral conversion of T4 into T3.
ISSN: 0926-5287
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Research Center
Animal Physiology and Neurobiology Section - miscellaneous
Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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