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Title: Ontogeny of the effect of purified chicken growth hormone on the liver 5' monodeiodination activity in the chicken : reversal of the activity after hatching
Authors: Darras, Veerle ×
Huybrechts, Leo
Berghman, Luc
Kühn, Eduard
Decuypere, Eddy #
Issue Date: Feb-1990
Publisher: Academic press inc jnl-comp subscriptions
Series Title: General and Comparative Endocrinology vol:77 issue:2 pages:212-220
Abstract: The ontogeny of the effect of chicken growth hormone (c-GH) on the liver 5′ monodeiodination (5′-D) activity was studied in chickens starting from 14-day-old embryos until 5-week-old chickens. Ten micrograms of the purified hormone was ibjected intravenously and after 2 hr, blood and liver samples were taken. In all embryonic stages tested, c-GH stimulated the peripheral thyroxine (T4) to triiodothyronine (T3) conversion as demonstrated by the increased plasma T3 level and liver 5′-D activity while the plasma reverse T3 (rT3) level was decreased. In chicks 1 day after hatching, GH was still able to increase the plasma T3 level and the liver 5′-D activity. However, in 2-day-old chicks, this stimulation had completely disappeared, while the control value of the plasma T3/T4 ratio was considerably higher than the day before. The effect of c-GH injection gradually turned into a decrease of 5′-D activity and plasma T3 in 5- and 7-day-old chicks. Further on, no effect of c-GH could be found in 2- to 4-week-old growing chickens, but in 5-week-old GH-injected animals the plasma T4 and rT3 level decreased again, although no significant effect on T3 or liver 5′-D activity could be demonstrated.
URI: 
ISSN: 0016-6480
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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