Biology of the neonate vol:58 issue:5 pages:291-295
The number of nuclear T3 receptors in the longissimus dorsi muscle has been determined in normal and runt (intrauterine growth-retarded) newborn piglets. Values of maximal binding capacity (B(max)), as calculated by Scatchard analysis, were 48.2 +/- 4.3 and 39.7 +/- 4.7 mol X 10(-14). mg DNA-1 (mean values +/- SEM) for controls and runts respectively (p < 0.01; n = 13 pairs of littermates). The lower B(max) in the runts may help to explain their reduced metabolic rate and lower respiratory enzyme activities in skeletal msucle, compared with controls of normal birth weight.