Title: The regulation of GH-dependent hormones and enzymes after feed restriction in dwarf and control chickens
Authors: Dewil, Erna ×
Darras, Veerle
Spencer, GSG
Lauterio, TJ
Decuypere, Eddy #
Issue Date: Mar-1999
Publisher: Pergamon-elsevier science ltd
Series Title: Life Sciences vol:64 issue:16 pages:1359-1371
Abstract: The principal objective of this study was to examine the GH-dependency of IGF-I and IGF-II changes in the chicken. To this end, the regulation of GH-dependent hormones and enzymes were studied in undernourished normal and dwarf chickens. The dwarf chickens examined exhibit a Laron-type dwarfism and have been shown to be GH receptor deficient. Thus, they provide an interesting model to determine the GH-dependency of IGF-I and IGF-II changes. Short (1 day) and long-term (7 days) feed restriction was imposed on growing normal and dwarf chickens to follow the subsequent endocrine changes. Since short-term feed restriction of dwarf chickens resulted in decreased plasma IGF-I, it appears that this is not a GH-dependent effect. However, with longer term undernutrition, IGF-I was not decreased in dwarf chickens. So, after a longer restriction period, the regulation of these factors appears to become more GH-dependent. IGF-II was not depressed at all by feed restriction in the dwarf chicken, suggesting a degree of GH-dependency.
ISSN: 0024-3205
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Research Center
Division of Livestock-Nutrition-Quality (-)
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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