Title: Portal vein thrombosis in a patient with HIV treated with a protease inhibitor-containing regimen
Authors: Soentjens, P ×
Ostyn, B
Van Outryve, S
Ysebaert, D
Vekemans, M
Colebunders, Robert #
Issue Date: Jan-2006
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:61 issue:1 pages:24-29
Abstract: We report a case of an HIV seropositive female patient treated with a protease inhibitor-containing regimen who developed recurrent severe life-threathening episodes of haematemesis over time, caused by ruptured oesophageal varices as a consequence of a portal vein thrombosis. Coagulation tests revealed a protein S deficiency, an elevated homocysteinemia and a constitutional elevated plasma factor VIII coagulant activity. These coagulopathies and the HIV infection are independent risk factors for developing venous thromboembolic events. The protease inhibitor treatment may have played a role in increasing the thromboembolic risk. The recurrent bleedings only stopped after invasive surgery. The invasive splenorenal shunt operation was in this case a life-saving procedure.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Faculty of Bioscience Engineering
× corresponding author
# (joint) last author

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