Performance of glomerular filtration rate estimation equations in Congolese healthy adults: The inopportunity of the ethnic correction

Bukabau, Justine B; Sumaili, Ernest K; Cavalier, Etienne; Pottel, Hans; Kifakiou, Bejos; Nkodila, Aliocha; Makulo, Jean Robert R; Mokoli, Vieux M; Zinga, Chantal V; Longo, Augustin L; Engole, Yannick M; Nlandu, Yannick M; Lepira, François B; Nseka, Nazaire M; Krzesinski, Jean Marie; Delanaye, Pierre

doi:10.1371/journal.pone.0193384

Performance of glomerular filtration rate estimation equations in Congolese healthy adults: The inopportunity of the ethnic correction

Author:

Bukabau, Justine B

Sumaili, Ernest K ; Cavalier, Etienne ; Pottel, Hans ; Kifakiou, Bejos ; Nkodila, Aliocha ; Makulo, Jean Robert R ; Mokoli, Vieux M ; Zinga, Chantal V ; Longo, Augustin L ; Engole, Yannick M ; Nlandu, Yannick M ; Lepira, François B ; Nseka, Nazaire M ; Krzesinski, Jean Marie ; Delanaye, Pierre

Keywords:

Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CHRONIC KIDNEY-DISEASE, SERUM CREATININE, CLINICAL-PRACTICE, AFRICAN-AMERICAN, RENAL-FUNCTION, CYSTATIN C, POSITION STATEMENT, PLASMA-CLEARANCE, GFR, PREDICTION, Adult, Algorithms, Creatinine, Cross-Sectional Studies, Cystatin C, Democratic Republic of the Congo, Ethnicity, Female, Glomerular Filtration Rate, Humans, Iohexol, Kidney Function Tests, Male, Middle Aged, Renal Insufficiency, Chronic, General Science & Technology

Abstract:

In the estimation of glomerular filtration rate (GFR), ethnicity is an important determinant. However, all existing equations have been built solely from Caucasian and Afro-American populations and they are potentially inaccurate for estimating GFR in African populations. We therefore evaluated the performance of different estimated GFR (eGFR) equations in predicting measured GFR (mGFR).