Title: Effect of recombinant human insulin-like growth factor-i on weight-gain, fat-content, and hormonal parameters in broiler-chickens
Authors: Huybrechts, Lm ×
Decuypere, Eddy
Buyse, Johan
Kuhn, Er
Tixierboichard, M #
Issue Date: Jan-1992
Publisher: Poultry science assoc inc
Series Title: Poultry science vol:71 issue:1 pages:181-187
Abstract: Osmotic minipumps were implanted in 4-wk-old female broiler chickens to supply a 2-wk continuous infusion of recombinant human insulin-like growth factor-I (rhIGF-I) in three doses (.03, .1, and.3 mg/kg BW per day). At the end of the experimental period no differences m BW were detected, although abdominal fat was significantly reduced in the highest dose group. Measurement of fat content in both breast and thigh muscle indicated a different effect of IGF-I treatment on these parameters, as no reduction was observed. Determination of circulating IGF-I levels revealed a twofold increase m the .3-mg group whereas the lowest dose chd not increase circulating plasma levels. The changes in IGF-I levels did not influence growth hormone levels whereas thyroxine levels were significantly decreased both m the .03- and .3-mg groups after 1 wk of treatment. At the same time Plasma triiodothyronine levels were increased in the .1- and .3-mg/kg groups. There results indicate that a continuous infusion of IGF-I did not increase weight gain but may play a role as a fat repartitioning agent.
ISSN: 0032-5791
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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