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Title: Developmental effects of monensin on drosophila-melanogaster
Authors: Callaerts, Patrick ×
De Loof, Arnold #
Issue Date: Nov-1993
Publisher: Springer verlag
Series Title: Rouxs archives of developmental biology vol:203 issue:1-2 pages:83-91
Abstract: Extracellular matrix and membrane proteins and their correct secretion probably are key elements in morphogenesis and differentiation in Drosophila. in this study, we have analysed the effects of monensin, a Na+-H+-ionophore which blocks normal secretion, applied during cellular blastoderm formation on further development. Normal cell morphology and intercellular contacts are lost and the extracellular matrix becomes disorganized. Gastrulation is blocked and abnormal foldings can be observed. Cuticle phenotypes showed different degrees of ventral, dorsal, head and posterior defects. The results are discussed in the context of what is known about membrane and extracellular matrix proteins in Drosophila.
ISSN: 0930-035X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Associated Laboratories - miscellaneous (-)
Department of Biology - miscellaneous
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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