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Title: Molecular evidence for the expression of angiotensin converting enzyme in hemocytes of Locusta migratoria: stimulation by bacterial lipopolysaccharide challenge
Authors: Macours, Nathalie ×
Hens, Korneel
Francis, Carmen
De Loof, Arnold
Huybrechts, Roger #
Issue Date: Aug-2003
Publisher: Pergamon-elsevier science ltd
Series Title: Journal of Insect Physiology vol:49 issue:8 pages:739-746
Abstract: The presence of angiotensin converting enzyme (ACE) in insects has been reported many times, but numerous questions about the functional role of this enzyme in insects remain. Here we show by RT-PCR experiments that ACE has a wide tissue distribution in Locusta migratoria, suggesting diverse roles for this enzyme in the locust. Immune challenge through injection of bacterial lipopolysaccharides resulted in a tenfold increase of ACE gene transcripts in the hemocytes and is suggestive for a role of ACE in the cellular defense of the locust. However, phenotypic knockout experiments with the ACE inhibitor captopril showed that ACE is not essential for the efficient clearance of injected E. coli bacteria. (C) 2003 Elsevier Science Ltd. All rights reserved.
URI: 
ISSN: 0022-1910
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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