Title: Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes
Authors: Macours, Nathalie ×
Poels, Jeroen
Hens, Korneel
Francis, Carmen
Huybrechts, Roger #
Issue Date: 2004
Publisher: Elsevier academic press inc
Series Title: International Review of Cytology - A Survey of Cell Biology vol:239 pages:47-97
Abstract: Angiotensin-converting enzyme, a member of the M2 metalloprotease family, and endothelin-converting enzyme, a member of the M13 family, are key components in the regulation of blood pressure and electrolyte balance in mammals. From this point of view, they serve as important drug targets. Recently, the involvement of these enzymes in the development of Alzheimer's disease was discovered. The existence of homologs of these enzymes in invertebrates indicates that these enzyme systems are highly conserved during evolution. Most invertebrates lack a closed circulatory system, which excludes the need for blood pressure regulators. Therefore, these organisms represent excellent targets for gaining new insights and revealing additional physiological roles of these important enzymes. This chapter reviews the structural and functional aspects of ACE and ECE and will particularly focus on these enzyme homologues in invertebrates.
ISSN: 0074-7696
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Macours et al._2004_Intl Rev Cytol_vol239_p47-97.pdf Published 10403KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science